Inotek's Recent Peroxynitrite Publications 

2005

Pieper G, Nilakantan V, Chen M, Zhou J, Khanna A, Henderson J, Johnson C, Roza A, Szabo C. 2005. Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplants.  JPET 314:53-60.

2004

Lacza Z, Horn T, Snipes J, Zhang J, Roychowdhury S, Horvath E, Figueroa J, Kollai M, Szabo C, Busija D. 2004.  Lack of mitochondrial nitric oxide production in the mouse brain. Journal of Neurochemistry 90: 942-951

Mabley J, Phil D, Southan G, Salzman A, Szabo C. 2004. The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vitro and interleukin-1B-induced suppression of  islet insulin secretion in vitro. Pancreas 28:e39-e44

2003

Lacza Z, Snipes JA, Zhang J, Horváth EM, Figueroa JP, Szabó C, Busija DW.  2003. Mitochondrial NO synthase is not eNOS, nNOS or iNOS. Free Rad Biol Med 35(10):1217-28.

Liaudet L, Szabó G, Szabó C. 2003. Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite – PARP connection. Coronary Artery Dis. 14:115-122.

Mabley JG, Southan GJ, Salzman AL, Szabó C. 2003. The combined inducible nitric oxide synthase inhibitor and free radical scavenger, guanidinoethyldisulphide, prevents multiple-low-dose-streptozotocin-induced diabetes in vivo and interleukin-1ß-induced suppression of islet insulin secretion in vitro. Pancreas 28(2):E39-44.

Naidu BV, Farivar AS, Woolley SM, Fraga C, Salzman AL, Szabó C, Groves JT, Mulligan MS. 2003. Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis. Exp Mol Pathol 75:12-7.

Naidu BV, Fraga C, Salzman AL, Szabó C, Verrier ED, Mulligan MS. 2003. Critical role of reactive nitrogen species in lung ischemia-reperfusion injury. J Heart Lung Transplant. 22: 784-93.

Naidu BV, Krishnadasan B, Fraga C, Thomas R, Salzman AL, Szabó C, Verrier ED, Mulligan MS. 2003. The critical role of reactive nitrogen species in lung ischemia reperfusion injury. J Heart Lung Transplant 22:784-793

Pacher P, Liaudet L, Bai P, Mabley JG, Kaminsky P, Virág L, Deb A, Szabó É, Ungvári Z, Wolin MS, Szabó C. 2003. A potent peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced heart failure. Circulation 107:896-904.

Szabó C. 2003. Multiple pathways of peroxynitrite toxicity. Toxicology Letters 140:105-112.

Virág L, Szabó E, Gergely P, Szabó C. 2003. Peroxynitrite- induced cytotoxicity: mechanisms and opportunities for intervention.  Toxicology Letters 140:113-124.

2002

Bianchi C, Wakiyama H, Faro R, Khan T, McCully J, Levitsky S, Szabó C, Sellke F. 2002. A novel peroxynitrite decomposition catalyst (FP-15) reduces heart infarct size in a model of acute ischemia-reperfusion. Ann Thorac Surg 74: 1201-7.

Ischiropoulos H, Ohshima H, Chen W, Hertkorn C, Lorch S, Weiss M, Lightfoot R, Souza J, Yermilov V, Pignatelli B, Masuda M, Szabó C. 2002. Detection of peroxynitrite-induced protein and DNA modifications. In: Oxidative Stress Biomarkers and Antioxidant Protocols. (D. Armstrong, Ed.) Methods in Molecular Biology, Volume 186. Humana Press (Totowa, NJ), pp. 77-88.

Lorch S, Lightfoot R, Ohshima H, Virág L, Chen Q, Hertkorn C, Weiss M, Souza J, Ischiropoulos H, Yermilov V, Pignatelli B, Masuda M, Szabó C. 2002. Detection of peroxynitrite-induced protein and DNA modifications. In: Oxidants and Antioxidants. Ultrastructure and Molecular Biology Protocols. (D. Armstrong, Ed.) Methods in Molecular Biology, Volume 196. Humana Press (Totowa, NJ), pp. 247-275.

Mabley JG, Liaudet L, Pacher P, Southan GJ, Salzman AL, Szabó C.  2002.  Beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis. Molecular Medicine 8: 581-90.

Shanley TP, Zhao B, Macariola DR, Denenberg A, Salzman AL, Ward PA. 2002. Role of nitric oxide in acute lung inflammation: lessons learned from the inducible nitric oxide synthase knockout mouse. Crit Care Med 30:1960-8.

Szabó C, Mabley J, Moeller SM, Shimanovich R, Pacher P, Virág L, Soriano FG, van Duzer JH, Williams W, Salzman AL, Groves JT. 2002. Pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst. Molecular Medicine 8:571-80.

2001

Eaves-Pyles T, Murthy K, Liaudet L, Virág L, Ross G, Soriano FG, Szabó C, Salzman AL. 2001. Flagellin: a novel mediator of Salmonella-induced systemic inflammation IkBa degradation, induction of nitric oxide synthase, induction of pro-inflammatory mediators and cardiovascular dysfunction. J Immunol 166:1248-1260.

Haskó G, Szabó C, Németh ZH, Deitch EA. 2001. Sulfasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, IL-12 production, and major histocompatibility complex II expression.  Immunology 103:473-478.

Lakey JRT, Suarez-Pinzon WL, Strynadka K, Korbutt GS, Rajotte RV, Mabley JG, Szabó C, Rabinovitch A. 2001. Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta-cells. Lab Invest 81:1683-1692.

Lohinai Z, Stachlewitz RF, Virág L, Székely A, Haskó G, Szabó C. 2001. Evidence for reactive nitrogen species formation in gingivomucosal tissues. J Dental Res 80:470-5.

Ploner F, Radermacher P, Theisen M, Tugetekin IF, Majetovic M, Stehr A, Szabó C, Southan GJ, Georgieff M, Bruckner UB, Trager K. 2001. Effects of combined selective iNOS inhibition and peroxynitrite blockade during endotoxemia in pigs. Shock 16:130-136.

Scott GS, Kean RB, Southan GJ, Szabó C, Hooper DC. 2001. Effect of mercapto-ethylguanidine scavengers of peroxynitrite on the development of experimental allergic encephalo-myelitis in PLSJL mice. Neurosci Lett 311:125-128.

Soejima K, Schmalstieg FC, Traber LD, Szabó C, Salzman A, Traber DL. 2001. Role of nitric oxide in myocardial dysfunction after combined burn and smoke inhalation injury. Burns 27:809-15.

Soejima K, Traber LD, Schmalstieg FC, Hawkins H, Jodoin JM, Szabó C, Szabó É, Virág L, Salzman A, Traber DL. 2001. Nebulized NO/nucleophile reduces pulmonary vascular resistance in mechanically ventillated septic sheep. Am J Resp Crit Care Med 163:745-52.

Soejima K, Traber LD, Schmalstieg FC, Jodoin JM, Szabó C, Szabó E, Virág L, Salzman AL, Traber DL. 2001. Effects of inducible nitric oxide synthase inhibition on vascular hyperpermeability after cutaneous burn and smoke inhalation combined injury in sheep. Am J Resp Crit Care Med 163:745-52.

Suarez-Pinzon WL, Mabley J, Szabó C, Rabinovitch A. 2001. Reduction of autoimmune diabetes in NOD mice by a selective inhibitor of the inducible nitric oxide synthase and scavenger of peroxynitrite. J Autoimmun 16:449-55.

Zsengellér ZK, Ross G, Trapnell BC, Szabó C, Whitsett JA. 2001. Adenovirus infection increases iNOS and peroxynitrite production in the lung. Am J Physiol 280:L503-511.

2000

Bank N, Kiroycheva M, Singhal PC, Anthony GM, Southan GJ, Szabó C. 2000. Inhibition of nitric oxide synthase ameliorates cellular injury in sickle cell mouse kidneys. Kidney Int 58:82-89.

Bernstein T, Szabó C, Salzman AL. 2000. Maturation-dependent sequential expression of interferon regulatory factor-1 and inducible nitric oxide synthase in cultured human enterocytes. Shock 14:514-21.

Liaudet L, Soriano FG, Szabó C. 2000. Biology of nitric oxide signaling. Crit Care Med 28 (Suppl):N37-N52.

Lorch SA, Foust R 3rd, Gow A, Arkovitz M, Salzman AL, Szabó C, Vayert B, Geffard M, Ischiropoulos H. 2000. Immunohistochemical localization of protein 3-nitrotyrosine and S-nitrosocysteine in a murine model of inhaled nitric oxide therapy. Pediatr Res 47:798-805.

Soejima K, McGuire R, Snyder N, Uchida T, Szabó C, Salzman AL, Traber LD, Traber DL. 2000. The effect of inducible nitric oxide synthase inhibition on smoke inhalation injury in sheep. Shock 13:261-6.

Szabó C. 2000. Anti-peroxynitrite strategies for the experimental therapy of shock. Crit Care Med 28:2156-7.

Szabó C. 2000. Role of nitric oxide in inflammation. In: Nitric Oxide - Biology and Pathobiology  (L. Ignarro, Ed). Academic Press, New York, 841-872.

Vincent JL, Zhang H, Szabó C, Preiser JC. 2000. Effects of nitric oxide in septic shock. Am J Resp Crit Care Med 161:1781-1785.

For a more comprehensive list of Inotek's Peroxynitrite publications, please download the following PDF file:  Peroxynitrite