Inotek Publications

Moon R, Parikh AA, Salzman AL, Szabó C, Fischer JE, Hasselgren PO. 1998. Complement C3 production in human intestinal epithelial cells is regulated by interleukin-1 and tumor necrosis factor. Arch Surg 132:1289-1293.

Cuzzocrea S, Zingarelli B, Hake P, Salzman AL, Szabó C. 1998. Carrageenan-induced local inflammation: effect of mercaptoethylguanidine, a selective inhibitor of the inducible nitric oxide synthase and a scavenger of peroxynitrite. Free Radical Biol Med 24:450-459. 2.53 MB PDF

Szabó C, Virág L, Cuzzocrea S, Scott GJ, Hake P, O'Connor M P, Zingarelli B, Salzman AL, Kun E. 1998. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-ribose) synthetase. Proc Natl Acad Sci USA 95:3867-3872. 403 kb PDF

Salzman AL, Pyles T, Denenberg A, Szabó C. 1998. Regulation of the induction of human inducible nitric oxide synthase by bacterial lipopolysaccharide and live bacteria in a human intestinal epithelial c.ll line. Gastroenterology 114:93-102. 1.61 MB PDF

Lohinai Z, Benedek P, Fehér E, Györfy A, Rosivall L, Fazekas á, Zelles T, Salzman AL, Szabó C. 1998. Protective effects of mercapto-ethylguanidine, a selective inhibitor of inducible nitric oxide synthase in ligature-induced periodontitis in the rat. Br J Pharmacol 123:353-360. 3.2 MB PDF

Szabó C. 1998. Potential role of the peroxynitrite-poly(ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shock. Shock 9:341-344. 514 kb PDF

Cuzzocrea S, Zingarelli B, Gilad E, Hake P, Salzman AL, Szabó C. 1998. Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation. Eur J Pharmacol 342:67-76. 4.3 MB PDF

Cuzzocrea S, Zingarelli B, O'Connor M, Salzman AL, Szabó C. 1998. Effect of L-buthionine-(S,R)-sulfoximine, an inhibitor of gamma-glutamyl-cysteine synthetase on the peroxynitrite- and endotoxic shock - induced vascular failure. Br J Pharmacol 123:525-537. 5.37 MB PDF

Haskó G, Szabó C, Németh ZH, Salzman AL, Vizi ES. 1998. Suppression of IL-12 production by phosphodiesterase inhibition in murine endotoxemia is IL-10 independent. Eur J Immunol 28:468-472. 581 kb PDF

Brahn E, Banquerigo ML, Firestein GS, Boyle DL, Salzman AL, Szabó C. 1998. Collagen-induced arthritis: reversal by mercaptoethylguanidine, a novel anti-inflammatory agent with a combined mechanism of action. J Rheumat 25:1785-1793 3.47 MB PDF

Haskó G, Szabó C, Németh Z, Vizi ES. 1998. Modulation by dantrolene of the endotoxin-induced IL-10, TNF-alpha and nitric oxide production in vivo and in vitro. Br J Pharmacol 124:1099-1106.

Ajuebor MN, Virág L, Flower RJ, Perretti M, Szabó C. 1998. Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation: relationship to IL-10 and chemokine production. Immunology 95:625-630. 1.03 MB PDF

Szabó A, Salzman AL, Szabó C. 1998. Inhibition of poly (ADP-ribose) synthetase ameliorates endotoxin-induced intestinal and pulmonary leakage. Life Sci 63:2133-2139. 885 kb PDF

Németh Z, Haskó G, Szabó C, Salzman AL, Vizi ES.1998. Calcium channel blockers and dantrolene differentially regulate the production of interleukin-12 and interferon-gamma in endotoxemic mice. Brain Res Bull 46:257-261.

Haskó G, Szabó C, Németh Z, Salzman AL, Vizi ES. 1998. Stimulation of b-adrenoceptors inhibits endotoxin-induced IL-12 production in mice. J Neuroimmunol 88:57-61. 989 kb PDF

Gilad E, Wong HR, Zingarelli B, Virág L, O'Connor M, Salzman AL, Szabó C. 1998. Melatonin inhibits the expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NF-κB activation. FASEB J 12:685-693. 1 MB PDF

Salzman AL. 1998. Endotoxic nitrosopenia. Intensive Care Med 24:1239-41

Pritts TA, Moon R, Fischer JE, Salzman AL, Hasselgren PO. 1998. Nuclear factor-kappaB is activated in intestinal mucosa during endotoxemia. Arch Surg 133:1311-5

Gardner PR, Costantino G, Salzman AL. 1998. Constitutive and adaptive detoxification of nitric oxide in Escherichia coli. Role of nitric-oxide dioxygenase in the protection of aconitase. J Biol Chem 273:26528-26533. 1.71 MB PDF

Gardner PR, Gardner AM, Martin LA, Salzman AL. 1998. Nitric oxide dioxygenase: an enzymic function for flavohemoglobin. Proc Natl Acad Sci USA 95:10378-10383. 1.93 MB PDF

Endres M, Scott GS, Namura S, Salzman AL, Moskowitz M, Szabó C. 1998. Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly (ADP-ribose) synthetase after cerebral ischemia-reperfusion. Neurosci Lett 248:29-32. 1.44 MB PDF

Panas D, Khadour FH, Szabó C, Schulz R. 1998. Pro-inflammatory cytokines depress cardiac efficiency by a nitric oxide-dependent mechanism. Am J Physiol 275:H1016-H1023 157 kb PDF

Zingarelli B, Virág L, Szabó A, Cuzzocrea S, Salzman AL, Szabó C. 1998. Oxidation, nitration and cytostasis induction in the absence of inducible nitric oxide synthase. Int J Mol Med 1:787-795. 3.28 MB PDF

Haskó G, Németh Z, Szabó C, Zsilla G, Salzman AL, Vizi ES. 1998. Isoproterenol inhibits IL-10, TNF and nitric oxide production in RAW 264.7 macrophages. Brain Res Bull 45:183-187. 1.02 MB PDF

Southan GJ, Salzman AL, Szabó C. 1998. Hydroxyguanidines inhibit peroxynitrite-induced oxidation. Free Rad Biol Chem 25:914-925. 1.88 MB PDF

Virág L, Haskó G, Salzman AL, Szabó C. 1998. NADPH-diaphorase histochemistry detects inducible nitric oxide synthetase (iNOS) activity in the thymus of naive and Staphylococcal enterotoxin B (SEB)-stimulated mice, J Histochem Cytochem 46:787-792. 347 kb PDF

Endres M, Scott GS, Salzman AL, Kun E, Moskowitz M, Szabó C. 1998. Protective effects of 5-iodo-6-amino-1,2-benzopyrone, a potent inhibitor of poly (ADP) ribose synthetase against peroxynitrite-induced astrocyte damage and stroke development. Eur J Pharmacol 351:377-382. 840 kb PDF

Haskó G, Shanley TP, Németh ZH, Salzman AL, Vizi ES, Szabó C. 1998. Exogenous and endogenous catecholamines inhibit the production of MIP-1alpha via a beta adrenoceptor mediated mechanism. Br J Pharmacol 125:1297-1303. 1.78 MB PDF

Zingarelli B, Cuzzocrea S, Szabó C, Salzman AL (1998) Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther 287:1048-1055. 999 kb PDF

Zingarelli B, Salzman AL, Szabó C. 1998. Genetic disruption of poly (ADP ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia-reperfusion injury. Circ Res, 83:85-94. 679 kb PDF

Virág L, Scott GS, Cuzzocrea S, Salzman AL, Szabó C. 1998. Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly-(ADP-ribose) synthetase (PARS) activation. Immunology 94:345-355. 3.75 MB PDF

Szabó C, Scott GS, Virág L, Egnaczyk G, Salzman AL, Shanley TP, Haskó G. 1998. Suppression of macrophage inflammatory protein (MIP)-1 alpha production and collagen-induced arthritis by adenosine receptor agonists. Br J Pharmacol 125:379-387. 3.79 MB PDF

Virág L, Marmer D, Szabó C. 1998. The crucial role of apopain/caspase-3 in the peroxynitrite-induced apoptotic DNA fragmentation, Free Rad Biol Med 25:1057-1065. 1.35 MB PDF

Virág L, Salzman AL, Szabó C. 1998. Poly (ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J Immunol 161: 3753-3759. 192 kb PDF

Szabó A, Hake P, Salzman AL, Szabó C. 1998. Inhibition of poly (ADP-ribose) synthetase exerts protective effects in a porcine model of hemorrhagic shock. Shock 10:347-353. 1.02 MB PDF

Bajor T, Southan GJ, Salzman AL, Szabó C, Hrabák A. 1998. Theoretical approximation of the partial selectivity of sulfur-based inhibitors of nitric oxide synthase (NOS) isoenzymes. Med Sci Mon 4:587-595.

Preiser JC, Szabó C. 1998. Inhaled nitric oxide in ARDS: is the question closed? Crit Care Med 27:846.

Szabó C. 1998. Molecular mechanisms of nitric oxide-induced vessel wall dysfunction in sepsis. Sepsis 1:107-114. 1.92 MB PDF

Szabó C. 1998. Role of poly (ADP-ribose) synthetase in inflammation. Eur J Pharmacol 350:1-19. 239 kb PDF

Salzman AL. 1998. Poly (ADP-Ribose) Synthetase Activation in Circulatory Shock. In: Update in Intensive Care and Emergency Medicine (Ed: W. J. Sibbald, K. Messmer, M. P. Fink), Springer-Verlag (Heidelberg, Germany), pp. 138-158.

Szabó C, Dawson VL. 1998. Role of poly (ADP-ribose) synthetase activation in inflammation and reperfusion injury. Trends Pharmacol Sci 19:287-298.