Inotek Publications

Zingarelli B, Haskó G, Salzman AL, Szabó C. 1999. Effects of a novel guanylyl cyclase inhibitor on the vascular actions of nitric oxide and peroxynitrite in immunostimulated smooth muscle cells and in endotoxic shock. Crit Care Med 27:1701-1707.

Szabó A, Hake P, Salzman AL, Szabó C. 1999. Beneficial effects of mercaptoethylguanidine, an inhibitor of the inducible isoform of nitric oxide synthase and a scavenger of peroxynitrite, in a porcine model of delayed hemorrhagic shock Crit Care Med 27:1343-1350. 1.07 MB PDF

Virág L, Szabó C. 1999. Chelation of zinc inhibits poly(ADP-ribose) synthetase (PARS) activation and protects against peroxynitrite-induced cytotoxicity. Br J Pharmacol 126:769-777. 2.69 MB PDF

Zingarelli B, Szabó C, Salzman AL. 1999. Poly (ADP-ribose) synthetase triggers a positive feedback cycle of neutrophil recruitment, oxidant generation, and mucosal injury in colitis. Gastroenterology 116:335-45 4.25 MB PDF

Eaves-Pyles T, Szabó C, Salzman AL. 1999. Bacterial adhesion mediates microbial activation of NF-κB in enterocytes. Infect Immun 67:800-4. 1.1 MB PDF

Scott GS, Jakeman L, Stokes B, Szabó C. 1999. Production of peroxynitrite and activation of poly (ADP-ribose) synthetase in spinal cord trauma. Ann Neurol 45:120-124. 3.66 MB PDF

Wilson L, Szabó C, Salzman AL. 1999. Protein kinase C-dependent activation of NF-kappaB in enterocytes is independent of IkappaB degradation. Gastroenterology 117:106-14

Zingarelli B, Szabó C, Salzman AL. 1999. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut 45: 199-209. 4.12 MB PDF

Whiteman M, Szabó C, Halliwell B. 1999. Modulation of the peroxynitrite and HOCl mediated inactivation of alpha-1 antiproteinase by mercaptoethylguanidine, a novel inhibitor of nitric oxide synthase and potent scavenger of peroxynitrite. Br J Pharmacol 126:1646-1652. 1.43 MB PDF

Ajuebor MN, Das AM, Virág L, Flower RJ, Szabó C, Perretti M. 1999. Role of resident peritoneal macrophages and mast cells on chemokine production and neutrophil migration in acute inflammation. Evidence for an inhibitory loop involving endogenous IL-10. J Immunol 162:1685-1691. 3.51 MB PDF

Grupp IL, Jackson TM, Hake P, Grupp G, Szabó C. 1999. Protection against hypoxia-reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working hearts. J Mol Cell Cardiol 31:297-303. 1.6 MB PDF

Moon R, Pritts TA, Parikh AA, Fischer JE, Salzman AL, Ryan M, Wong HR, Hasselgren PO. 1999. Stress response decreases the interleukin-1beta-induced production of complement component C3 in human intestinal epithelial cells. Clin Sci (Lond) 97:331-337.

Hrabie JA, Saavedra JE, Roller PP, Southan GJ, Keefer LK. 1999. Conversion of proteins to diazeniumdiolate-based nitric oxide donors. Bioconjug Chem 10:838-42.

Wolfard A, Kaszaki J, Szabó C, Balogh Z, Nagy S, Boros M. 1999. Effect of selective nitric oxide synthase inhibition in hyperdynamic endotoxemia in dogs. Eur J Surg Res 31:314-323.

Szabó C. 1999. Simultaneous targeting of multiple pathways of shock: how promising? How novel? Shock 11:296-297.

Moon MR, Parikh AA, Pritts TA, Fischer JE, Cottongim S, Szabó C, Salzman AL, Hasselgren PO. 1999. Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha. J Surg Res 82:48-55.

Kennedy M, Wilson L, Denenberg AG, Szabó C, Salzman AL. 1999. 5-ASA inhibits iNOS transcription in human enterocytes: role of IRF-1. Int J Mol Med 4:437-443

Virág L, Scott GS, Antal-Szalmás P, O'Connor M, Ohshima H, Szabó C. 1999. Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase (PARS) activation and cytotoxicity. Mol Pharmacol 56:824-833. 399 kb PDF

Ajuebor MN, Das AM, Virág L, Szabó C, Perretti M. 1999. Regulation of macrophage inflammatory protein-1alpha expression and function by endogenous IL-10 in a model of acute inflammation. Biochem Biophys Res Comm 255:279-282.

Szabó C. 1999. Nitric oxide and PARS. In: Pathophysiology and Clinical Applications of Nitric Oxide, (ed: GM Rubanyi), Harwood Academic Publishers. Chapter 6, pp. 69-98.

Southan GJ, Szabó C, Thiemermann C. 1999. Inhibitors of nitric oxide synthesis. In: The Hemodynamic Effects of Nitric Oxide (Ed: RT Mathie, TM Griffith). Imperial College Press, London, pp. 127-163.

Haskó G, Németh ZH, Salzman AL, Vizi ES, Szabó C. 1999. An agonist of A3 adenosine receptors decreases IL-12, IFN and nitric oxide production and prevents lethality in endotoxemic mice. Eur J Pharmacol 358:261-268. 1.2 MB PDF

Southan GJ, Srinivasan A. 1999. Nitrogen oxides and hydroxyguanidines: formation of donors of nitric and nitrous oxides and possible relevance to nitrous oxide formation by nitric oxide synthase. Nitric Oxide 2:270-86

Whalen MJ, Clark RSB, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham S, Virág L, Haskó G, Stachlewitz RF, Szabó C, Kochanek P. 1999 Reduction in deficits of memory and motor function after traumatic brain injury in mice deficient in poly (ADP-ribose) polymerase. J Cerebr Blood Flow Metabol 19:835-842. 1.92 MB PDF

Virág L, Scott GS, Antal-Szalmás P, O'Connor M, Ohshima H, Szabó C. 1999. Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase (PARS) activation and cytotoxicity. Mol Pharmacol 56:824-833.

Moon R, Pritts TA, Parikh AA, Fischer JE, Salzman AL, Ryan M, Wong HR, Hasselgren PO. 1999. Stress response decreases the interleukin-1beta-induced production of complement component C3 in human intestinal epithelial cells. Clin Sci (Lond). 97:331-7.

Haskó G, Szabó C. 1999. Modulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system. Biochem Pharmacol 56:1079-1087. 2 MB PDF

Szabó C. 1999. Role of peroxynitrite and poly (ADP-ribose) synthetase in shock, inflammation, and ischemia-reperfusion injury. In: Recent Advances in Nitric Oxide (A. Kitabatake, I Sakuma, eds). Springer Verlag, Tokyo, pp. 3-20.

Szabó C, Billiar TR. 1999. Novel roles of nitric oxide in hemorrhagic shock. Shock 12:1-9. 1.88 MB PDF

Szabó C, Csont T, Szabó A, Zingarelli B, Cuzzocrea S, Salzman AL, Southan GJ. 1999. Peroxynitrite: the dark side of nitric oxide. Effects of mercaptoethylguanidine, a combined inhibitor of the inducible nitric oxide synthase and a scavenger of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. In: Nitric Oxide and Its Inhibition in Shock, Sepsis and Organ Failure (Schlag G, Redl H. Eds). Springer Verlag, Berlin, 203-244.

Haskó G, Szabó C. 1999. IL-12 as a therapeutic target for pharmacological modulation in immune-mediated and inflammatory diseases: regulation of T-helper1/T-helper 2 responses. Br J Pharmacol 127:1295-1304. 2.58 MB PDF

Haskó G, Kuhel DG, Chen JF, Schwarzschild MA, Deitch EA, Mabley JG, Marton A, Szabó C. 1999. Adenosine inhibits IL-12 and TNF-a production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J 14:2065-74. 346 kb PDF