Inotek Publications

Soriano FG, Virág L, Jagtap P, Szabó É, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KGK, Salzman AL, Southan GJ, Szabó C. 2001. Diabetic endothelial dysfunction: the role of poly (ADP-ribose) polymerase activation. Nature Medicine 7:108-113. 1.2 MB PDF

Virág L, Szabó C. 2001. Purines inhibit the activation of poly(ADP-ribose) synthetase: implications for the pathophysiology of ischemia-reperfusion injury. FASEB J 15:99-107. 375 kb PDF

Soejima K, Traber LD, Schmalstieg FC, Hawkins H, Jodoin JM, Szabó C, Szabó É, Virág L, Salzman AL, Traber DL. 2001. Nebulized NO/nucleophile reduces pulmonary vascular resistance in mechanically ventillated septic sheep. Am J Resp Crit Care Med 163:745-52.

Eaves-Pyles T, Murthy KGK, Liaudet L, Virág L, Ross G, Soriano FG, Szabó C, Salzman AL. 2001. Flagellin: a novel mediator of Salmonella-induced systemic inflammation IkBa degradation, induction of nitric oxide synthase, induction of pro-inflammatory mediators and cardiovascular dysfunction. J Immunol 166:1248-1260. 3.7 MB PDF

Haskó G, Szabó C, Németh ZH, Deitch EA. 2001. Sulfasalazine inhibits macrophage activation: inhibitory effects on inducible nitric oxide synthase expression, IL-12 production, and major histocompatibility complex II expression. Immunology 103:473-478.

Yang Z, Szabó C. 2001. The production of IL-12 is under the control of endogenous interleukin-10 in myocardial ischemia-reperfusion. Shock 15:77-79. 820 kb PDF

Soriano FG, Liaudet L, Marton A, Haskó G, Lorigados CB, Deitch EA, Szabó C. 2001. Inosine improves gut permeability and vascular reactivity in endotoxic shock. Crit Care Med 29:703-708. 323 kb PDF

Lohinai Z, Stachlewitz RF, Virág L, Székely A, Haskó G, Szabó C. 2001. Evidence for reactive nitrogen species formation in gingivomucosal tissues. J Dental Res 80:470-5.

Mabley JG, Suarez-Pinzon WL, Haskó G, Salzman AL, Rabinovitch A, Kun E, Szabó C. 2001. Inhibition of poly (ADP-ribose) synthetase either by gene disruption or by enzyme inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple, low-dose, streptozotocin-induced diabetes and islets of Langerhans from cytokine-mediated dysfunction. Br J Pharmacol 133:909-919. 287 kb PDF

Szabó É, Virág L, Bakondi E, Gyüre L, Haskó G, Hunyadi J, Gergely P, Szabó C. 2001. Peroxynitrite-induced poly(ADP-ribose) polymerase activation in keratinocytes: implications for contact hypersensitivity. J Invest Dermatol 117:74-80. 220 kb PDF

Scott GS, Kean RB, Southan GJ, Szabó C, Hooper DC. 2001. Effect of mercapto-ethylguanidine scavengers of peroxynitrite on the development of experimental allergic encephalo-myelitis in PLSJL mice. Neurosci Lett 311:125-128.

Ploner F, Radermacher P, Theisen M, Tugetekin IF, Majetovic M, Stehr A, Szabó C, Southan GJ, Georgieff M, Bruckner UB, Trager K. 2001. Effects of combined selective iNOS inhibition and peroxynitrite blockade during endotoxemia in pigs. Shock 16:130-136.

Liaudet L, Yang Z, Affar B, Szabó C. 2001. Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase. Molecular Medicine 7:406-417. 983 kb PDF

Liaudet L, Mabley JG, Soriano FG, Pacher P, Marton A, Haskó G, Szabó C. 2001. Inosine reduces sytemic inflammation and improves survival in septic shock induced by cecal ligation and puncture. Am J Resp Crit Care Med 164:1213-20. 111 kb PDF

Andreassen OA, Dedeoglu A, Friedlich A, Ferrante KL, Hughes D, Szabó C, Beal MF. 2001. Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylsegiline, trientine and lipoic acid in transgenic ALS mice. Exp Neurol 168:419-424.

Mabley JG, Jagtap P, Perretti M, Getting SJ, Salzman AL, Virág L, Szabó É, Soriano FG, Liaudet L, Abdelkarim GE, Haskó G, Marton A, Southan GJ, Szabó C. 2001. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm Res 50:561-569. 633 kb PDF

Bai P, Bakondi E, Szabó É, Gergely P, Szabó C, Virág L. 2001. Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxicity in thymocytes. Free Rad Biol Med 31:1616-1623. 226 kb PDF

Suarez-Pinzon WL, Mabley JG, Szabó C, Rabinovitch A. 2001. Reduction of autoimmune diabetes in NOD mice by a selective inhibitor of the inducible nitric oxide synthase and scavenger of peroxynitrite. J Autoimmun 16:449-55. 134 kb PDF

Lohinai Z, Stachlewitz RF, Székely AD, Fehér E, Dézsi L, Szabó C. 2001. Evidence for the expression of cyclooxygenase-2 in periodontitis. Life Sci 70: 279-290. 2.25 MB PDF

Soejima K, Traber LD, Schmalstieg FC, Jodoin JM, Szabó C, Szabó E, Virág L, Salzman AL, Traber DL. 2001. Effects of inducible nitric oxide synthase inhibition on vascular hyperpermeability after cutaneous burn and smoke inhalation combined injury in sheep. Am J Resp Crit Care Med 163:745-52. 2.09 MB PDF

Scott GS, Hake P, Kean, RB, Virág L, Szabó C, Hooper DC. 2001. Role of poly (ADP ribose) synthetase activation in the development of experimental allergic encelphalomyelitis. J Neuroimunol 117:78-86. 1.59 MB PDF

Lakey JRT, Suarez-Pinzon WL, Strynadka K, Korbutt GS, Rajotte RV, Mabley JG, Szabó C, Rabinovitch A. 2001. Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta-cells. Lab Invest 81:1683-1692. 331 kb PDF

Abdelkarim GE, Gertz K, Harms C, Katchanov J, Dirnagl U, Szabó C, Endres M. 2001. Protective effects of PJ34, a novel, potent inhibitor of poly (ADP-ribose) polymerase in in vitro and in vivo models of stroke. Int J Mol Med 7:255-260. 1.47 MB PDF

Soriano FG, Mabley JG, Pacher P, Liaudet L, Szabó C. 2001. Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase. Circ Res 89:684-691. 773 kb PDF

Soejima K, Schmalstieg FC, Traber LD, Szabó C, Salzman AL, Traber DL. 2001. Role of nitric oxide in myocardial dysfunction after combined burn and smoke inhalation injury. Burns 27:809-15. 127 kb PDF

Marton A, Pacher P, Murthy KGK, Németh ZH, Haskó G, Szabó C. 2001. Anti-inflammatory effects of inosine in human monocytes, neutrophils and epithelial cells in vitro Int J Mol Med 8:617-21. 161 kb PDF

Zsengellér ZK, Ross G, Trapnell BC, Szabó C, Whitsett JA. 2001. Adenovirus infection increases iNOS and peroxynitrite production in the lung. Am J Physiol 280:L503-511. 2.05 MB PDF

Németh ZH, Mabley JG, Deitch EA, Szabó C, Haskó G. 2001. Inhibition of the Na+/H+ antiporter suppresses IL-12 production in mouse macrophages. Biochem Biophys Acta 1539:233-242. 1.95 MB PDF

Liaudet L, Szabó E, Timashpolsky L, Virág L, Cziraki A, Szabó C. 2001. Localization of poly (ADP-ribose) polymerase (PARP) activation in a rat model of myocardial reperfusion injury: suppression of PARP activation and long-term morphological and functional improvement by 3-aminobenzamide. Br J Pharmacol 133:1424-1430. 317 kb PDF

Mabley JG, Liaudet L, Soriano FG, Virág L, Jagtap P, Marton A, Lorigados CB, Gallyas F, Szabó É, Abdelkarim GE, Haskó G, Southan GJ, Salzman AL, Szabó C. 2001. Local and Systemic Inflammation: Role of Poly (ADP-Ribose) Synthetase Activation by Reactive Nitrogen Species. In (Salv