Inotek Publications

Haskó G, Szabó C, Németh ZH, Deitch EA. 2002. Dopamine suppresses IL-12 p40 production by lipopolysaccharide-stimulated macrophages via a beta-adrenoceptor-mediated mechanism. J Neuroimmunol 122: 185-190. 1.55 MB PDF

Bakondi E, Bai P, Szabó É, Hunyadi J, Gergely P, Szabó C, Virág L. 2002. Detection of poly(ADP-ribose) polymerase activation in oxidatively stressed cells and tissues by using biotinylated NAD substrate. J Histochem Cytochem 50: 91-98. 274 kb PDF

Liaudet L, Murthy KGK, Mabley JG, Pacher P, Soriano FG, Salzman AL, Szabó C. 2002. Comparison of inflammation, organ damage and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and Serovar Enteriditis lipopolysaccharide. Infect Immun 70: 192-198. 140 kb PDF

Mabley JG, Haskó G, Liaudet L, Soriano FG, Southan GJ, Salzman AL, Szabó C. 2002. NF-κB1 (p50) deficient mice are not susceptible to multiple low dose streptozotocin induced diabetes. Endocrinology 173:457-464. 130 kb PDF

Mabley JG, Salzman AL, Szabó C. 2002. Nicotine reduces the incidence of multiple low dose streptozotocin induced and spontaneous diabetes in mice. J Pharmacol Exp Ther 300:876-81. 139 kb PDF

Pacher P, Liaudet L, Bai P, Virág L, Mabley JG, Haskó G, Szabó C. 2002. Activation of poly(ADP-ribose) polymerase contributes to the development of doxorubicin-induced heart failure. J Pharmacol Exp Ther 300:862-7. 343 kb PDF

Szabó G, Bährle S, Stumpf N, Sonnenberg K, Szabó É, Dengler TJ, Pacher P, Csont T, Schulz R, Jagtap P, Southan GJ, Liaudet L, Szabó C. 2002. A novel potent poly (ADP-ribose) polymerase inhibitor reduces reperfusion injury after heart transplantation. Circ Res 90:100-106. 316 kb PDF

Liaudet L, Mabley JG, Pacher P, Virág L, Soriano FG, Marton A, Haskó G, Deitch EA, Szabó C. 2002. Inosine exerts a broad range of anti-inflammatory effects in a murine model of acute lung injury. Ann Surg 235:568-578. 726 kb PDF

Pacher P, Liaudet L, Soriano FG, Mabley JG, Szabó É, Szabó C. 2002. The role of poly(ADP-ribose) polymerase in the development of myocardial and endothelial dysfunction in diabetes mellitus. Diabetes 51: 514-521. 555 kb PDF

Soriano FG, Liaudet L, Szabó É, Virág L, Mabley JG, Pacher P, Szabó C. 2002. Resistance against acute septic peritonitis in poly(ADP-ribose) polymerase deficient mice. Shock 17:286-292. 1.0 MB PDF

Németh Z, Deitch EA, Szabó C, Fekete G, Hauser CJ, Haskó G. 2002. Lithium induces NF-κB activation and IL-8 production in human intestinal epithelial cells. J Biol Chem 277:7713-7719. 1.45 MB PDF

Pacher P, Mabley JG, Soriano FG, Liaudet L, Komjáti K, Szabó C. 2002. Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation. Br J Pharmacol 135:1347-1350. 165 kb PDF

Jagtap P, Soriano FG, Virág L, Liaudet L, Mabley JG, Szabó E, Haskó G, Marton A, Lorigados CB, Gallyas F, Sumegi B, Huang H, Holyt DG, Salzman AL, Southan GJ, Szabó C. 2002. Novel phenanthridinone inhibitors of poly(ADP-ribose) synthetase: potent cyto-protective and anti-shock agents. Crit Care Med 30:1071-1082. 1.26 MB PDF

Goldfarb RD, Marton A, Szabó E, Virág L, Glock D, McCarthy R, Parrillo JE, Szabó C. 2002. Protective effect of a novel, potent inhibitor of poly (ADP-ribose) synthetase in a porcine model of severe bacterial sepsis. Crit Care Med 30:974-980. 1.05 MB PDF

Liaudet L, Pacher P, Virág L, Soriano FG, Haskó G, Szabó C. 2002. Activation of poly(ADP-ribose) polymerase is a central mechanism of lipopolysaccharide-induced acute pulmonary inflammation. Am J Resp Crit Care Med 165:372-377. 121 kb PDF

Kirov MY, Evgenov OV, Kuklin VN, Southan GJ, Salzman AL, Szabó C, Bjertnaes L. 2002. Aesorolized linear polyethylenimine-NONOATE attenuates endotoxin-induced lung injury in sheep. Am J Respir Crit Care Med, 166:1436-42. 149 kb PDF

Haskó G, Deitch EA, Németh ZH, Kuhel DG, Szabó C. 2002. Inhibitors of ATP binding cassette transporters suppress IL-12 and TNF production and MHCII upregulation in macrophages. J Pharmacol Exp Ther 301:103-110. 1.76 MB PDF

Pacher P, Liaudet L, Soriano FG, Komjati K, Mabley JG, Szabó C. 2002. The role of poly(ADP-ribose) polymerase in the development of chronic heart failure. J Am Coll Cardiol 40: 1006-16. 614 kb PDF

Faro R, Toyoda Y, McCully J, Jagtap P, Szabó E, Virág L, Bianchi C, Levitsky S, Szabó C, Sellke F. 2002. Protective effect on regional myocardial function and infarct size induced by PJ34: a novel poly (ADP-ribose) synthetase inhibitor. Ann Thorac Surg 73:575-581. 237 kb PDF

Szabó C, Mabley JG, Moeller SM, Shimanovich R, Pacher P, Virág L, Soriano FG, van Duzer JH, Williams W, Salzman AL, Groves JT. 2002. Pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst. Molecular Medicine 8:571-80. 155 kb PDF

Scott GS, Virág L, Szabó C, Hooper DC. 2002. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly (ADP-ribose) polymerase activation. Glia, 41: 105-16.

Németh ZH, Deitch EA, Lu Q, Szabó C, Haskó G. 2002. NHE blockade inhibits chemokine production and NF-κB activation in immunostimulated endothelial cells. Am J Physiol 283:C396-403. 1.75 MB PDF

Haskó G, Mabley JG, Pacher P, Liaudet L, Szabó C. 2002. Central role of poly(ADP-ribose) polymerase in the control of chemokine production. Mol Medicine, 8: 283-9. 636 kb PDF

Mabley JG, Liaudet L, Pacher P, Southan GJ, Salzman AL, Groves JT, Szabó C. Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis. Mol Med. 2002 Oct;8(10):581-90.. 195 kb PDF

Naidu BV, Krishnadasan B, Fraga C, Thomas R, Salzman AL, Szabó C, Verrier ED, Mulligan MS. 2002. The critical role of reactive nitrogen species in lung ischemia reperfusion injury. J Heart Lung Transplant 21:135. 273 kb PDF

Zhang X, Chen J, Graham SH, Du L, Kochanek PM, Draviam R, Guo F, Nathaniel PD, Szabó C, Watkins SC, Clark RSB. 2002. Intranuclear localization of apoptosis-inducing factor and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. J Neurochem 82:181-191.

Pacher P, Mabley JG, Soriano FG, Liaudet L, Komjáti K, Szabó C. 2002. Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging. Int J Mol Med, 9: 659-664. 157 kb PDF

Shanley TP, Zhao B, Macariola DR, Denenberg A, Salzman AL, Ward PA. 2002. Role of nitric oxide in acute lung inflammation: lessons learned from the inducible nitric oxide synthase knockout mouse. Crit Care Med. 30:1960-8.

Bianchi C, Wakiyama H, Faro R, Khan T, McCully J, Levitsky S, Szabó C, Sellke F. 2002. A novel peroxynitrite decomposition catalyst (FP-15) reduces heart infarct size in a model of acute ischemia-reperfusion. Ann Thorac Surg, 74: 1201-7.

Satchell A, Kochanek PM, Dixon CE, Melick J, Szabó C, Clark RSB. 2002. Role of poly(ADP-Ribose) polymerase-1 in spatial memory acquisition after traumatic brain injury in mice. J Neurosci, in press.

Szabó C, Zanchi A, Komjáti K, Pacher P, Krolewski AS, Quist WC, Horton ES, LoGerfo FW, Veves A. 2002. Poly(ADP-Ribose) polymerase-1 is activated in subjects at risk of developing Type 2 diabetes and is associated with impaired vascular reactivity. Circulation, 106: 2680-6. 563 kb PDF

Pacher P, Cziráki A, Papp L, Mabley JG, Szabó C. 2002. Role of poly(ADP-ribose) polymerase activation in the endotoxin-induced cardiac collapse in rodents. Biochem Pharmacol, 64: 1785-91. 451 kb PDF

Németh ZH, Deitch EA, Szabó C, Haskó G. 2002. Hyperosmotic stress induces NF-κB activation and IL-8 production in intestinal epithelial cells. Am J Pathol 161:987-96. 1.77 MB PDF

Ischiropoulos H, Ohshima H, Chen W, Hertkorn C, Lorch S, Weiss M, Lightfoot R, Souza J, Yermilov V, Pignatelli B, Masuda M, Szabó C. 2002. Detection of peroxynitrite-induced protein and DNA modifications. In: Oxidative Stress Biomarkers and Antioxidant Protocols. (D. Armstrong, Ed.) Methods in Molecular Biology, Volume 186. Humana Press (Totowa, NJ), pp. 77-88.

Lorch S, Lightfoot R, Ohshima H, Virág L, Chen Q, Hertkorn C, Weiss M, Souza J, Ischiropoulos H, Yermilov V, Pignatelli B, Masuda M, Szabó C. 2002. Detection of peroxynitrite-induced protein and DNA modifications. In: Oxidants and Antioxidants. Ultrastructure and Molecular Biology Protocols. (D. Armstrong, Ed.) Methods in Molecular Biology, Volume 196. Humana Press (Totowa, NJ), pp. 247-275.

Virág L, Szabó C. 2002. The therapeutic potential of PARP inhibition. Pharmacological Reviews, 54: 1-54. 707 kb PDF

Szabó C. 2002. Role of PARP activation in the pathophysiology of shock and inflammation. In: Therapeutic Implications of PARP Inhibition (Zhang J, Ed), CRC Press, Boca Raton, Florida, 169-204.

Mabley JG, Virág L, Szabó C. 2002. Role of PARP activation in the pathogenesis of diabetes and diabetic vascular dysfunction. In: Therapeutic Implications of PARP Inhibition (Zhang J, Ed), CRC Press, Boca Raton, Florida, 277-319. 4.88 MB PDF

Szabó C. 2002. PARP as a drug target for the therapy of diabetic cardiovascular dysfunction. Drug News Perspect 15:197-205. 140 kb PDF

Szabó C, Liaudet L. 2002. Myocardial ischemia-reperfusion injury: role of the peroxynitrite-poly (ADP-ribose) synthetase pathway. In: Yearbook of Intensive Care and Emergency Medicine (Ed: J.L. Vincent), Springer-Verlag (Heidelberg, Germany), pp. 165-176.

Liaudet L, Deb A, Pacher P, Mabley JG, Murthy KGK, Salzman AL, Szabó C. 2002. The flagellin - TLR5 pathway: therapeutic opportunities. Drug News Perspect 15: 397-409. 419 kb PDF

Haskó G, Deitch EA, Szabó C, Németh ZH, Vizi ES. 2002. Adenosine: a potential mediator of immunosuppression in multiple organ failure. Current Opinion in Pharmacology 2:440-444.