Inotek Publications

Liaudet L, Szabó C, Evgenov OV, Murthy KGK, Pacher P, Virág L, Mabley JG, Marton A, Soriano FG, Kirov M, Bjertnaes LJ, Salzman AL. 2003. Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock 19:131-7. 501 kb PDF

Mabley JG, Liaudet L, Pacher P, Soriano FG, Haskó G, Marton A, Salzman AL, Szabó C. 2003. Inosine reduces inflammation and improves survival in a murine model of colitis. Am J Physiol 284:G138-44. 413 kb PDF

Pacher P, Liaudet L, Bai P, Mabley JG, Kaminsky P, Virág L, Deb A, Szabó É, Ungvári Z, Wolin MS, Groves JT, Szabó C. Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation. 2003 Feb 18;107(6):896-904.602 kb PDF

Németh ZH, Deitch EA, Szabó C, Haskó G. 2003. Pyrrolidinedithiocarbamate inhibits NF-κB activation and IL-8 production in intestinal epithelial cells. Immunol Lett 85:41-6.

Iványi Z, Hauser B, Pittner A, Asfar P, Vassilev D, Nalos M, Altherr J, Brückner UB, Szabó C, Radermacher P, Fröba G. 2003. Systemic and hepato-splanchnic hemodynamic and metabolic effects of the PARS inhibitor PJ34 during hyperdynamic porcine endotoxemia. Shock, 19:415-421. 416 kb PDF

Pacher P, Mabley JG, Liaudet L, Evgenov OV, Southan GJ, Szabó C, Salzman AL. 2003. Topical administration of a novel nitric oxide donor, DS1, selectively increases vaginal blood flow in anesthetized rats. Int J Impotence Research, in press. 108 kb PDF

Mabley JG, Soriano FG, Pacher P, Haskó G, Marton A, Wallace R, Salzman AL, Szabó C. 2003. The adenosine A3 receptor agonist N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, reduces inflammation and oxidative damage in two murine models of colitis. Eur J Pharmacol, 466:323-329. 195 kb PDF

Scott GS, Virág L, Szabó C, Hooper DC. 2003. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly (ADP-ribose) polymerase activation. Glia, 41:105-16. 281 kb PDF

Bakondi E, Gönczi M, Szabó É, Bai P, Pacher P, Gergely P, Kovács L, Hunyadi J, Szabó C, Csernoch L, Virág L. 2003. Intracellular calcium and cell density-dependent signalling regulate oxidative stress sensitivity of HaCaT keratinocytes. J Invest Dermatol, 121:88-95. 318 kb PDF

Veres B, Gallyas F, Berente Z, ösz E, Szekeres G, Szabó C, Sümegi B. 2003. The novel phenanthridinone inhibitor of poly(ADP-ribose) synthetase (PJ34) protects mice against LPS induced septic shock by decreasing inflammatory response and enhancing the cytoprotective Akt/protein kinase B pathway. Biochem Pharmacol 65:1373-1382. 596 kb PDF

Pinhal-Enfield G, Ramanathan M, Haskó G, Vogel SN, Salzman AL, Boons GJ, Leibovich SJ. 2003. An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol 163:711-21.

Szabó G, Buhmann V, Andrási T, Stumpf N, Bahrle S, Kékesi V, Hagl S, Szabó C, Juhász-Nagy A 2003. Poly (ADP-ribose) polymerase (PARP)- inhibition protects against myocardial and endothelial reperfusion injury after hypothermic cardiac arrest. J Cardiothor Vasc Surg, in press.

Evgenov OV, Pacher P, Mabley JG, Síkó Z, Szabó C, Salzman AL. 2003. Intramuscular administration of glipizide, an inhibitor of ATP-sensitive potassium channels prolongs survival after severe controlled hemorrhage in rats. Crit Care Med, in press. 481 kb PDF

Piconi L, Quagliaro L, Da Ros R, Marini C, Giugliano D, Esposito K, Szabó C, Ceriello A. 2003. Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase. Am J Physiol, in press.

Soriano FG, Liaudet L, Pacher P, Mabley JG, Salzman AL, Szabó C. 2003. Protective effects of a potent peroxynitrite decomposition catalyst in murine LPS inflammation and CLP sepsis. Shock, in press.

Huang H, McIntosh J, Jones CB, Szabó C, Hoyt DG 2003. Poly(ADP-ribose) polymerase modulates endotoxin-induced DNA strand breakage and its inhibition by integrins in mouse lung endothelial cells. Int J Mol Med, in press

Satchell A, Kochanek PM, Dixon CE, Jenkins LW, Melick J, Szabó C, Clark RSB 2003. A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma. J Neurochem, 85:697-708. 334 kb PDF

Mabley JG, Suarez-Pinzon WL, Haskó G, Pacher P, Power R, Southan GJ, Salzman AL, Rabinovich A, Szabó C. 2003. Inosine protects against diabetes development in multiple low dose streptozotocin and NOD mouse models of type I diabetes. Mol Med, 9:96-104 670 kb PDF

Lacza Z, Horváth EM, Komjáti K, Hortobágyi T, Szabó C, Busija DW 2003. PARP inhibition improves the effectiveness of neural stem cell transplantation in experimental brain trauma. Int J Mol Med, 12:153-9.

Du L, Zhang X, Han YY, Burke NA, Kochanek PM, Watkins SC, Reynolds IJ, Graham SH, Carcillo JA, Szabó C, Clark RSB 2003. A direct role for mitochondrial poly(ADP-ribose) polymerase in apoptosis. J Biol Chem, 278:18426-33 645 kb PDF

Németh ZH, Deitch EA, Davidson MT, Szabó C, Haskó G 2003. Disruption of the actin cytoskeleton results in nuclear factor kB activation and inflammatory mediator production in human intestinal epithelial cells. J Cell Physiol, in press.

Shimoda K, Murakami K, Traber LL, Cox RA, Hawkins HK, Schmalstieg FC, Szabó C, Salzman AL, Traber DL. 2003. Effect of poly(ADP-ribose) synthetase inhibition on burn and smoke inhalation injury in the sheep. Am J Physiol, 285:L240-L249. 521 kb PDF

Lacza Z, Snipes JA, Miller AW, Szabó C, Grover G, Busija DW 2003. Heart mitochondria contain functional ATP-dependent K+ channels. J Mol Cell Cardiol, in press.

Lacza Z, Snipes JA, Zhang J, Horváth Em, Figueroa JP, Szabó C, Busija DW 2003. Mitochondrial NO synthase is not eNOS, nNOS or iNOS. Free Rad Biol Med, in press.

Khan TA, Ruel M, Bianchi C, Voisine P, Li J, Baker J, Komjáti K, Szabó C, Sellke FW. 2003. Poly-ADP-Ribose synthetase inhibition improves postischemic myocardial function after cardiopulmonary bypass. J Am Coll Surg, 197:270-277. 249 kb PDF

Németh Z, Leibovich J, Deitch EA, Vizi SE, Szabó C, Haskó G. 2003. cDNA microarray analysis reveals a NF-κB- independent regulation of macrophage function by adenosine. J Pharmacol Exp Ther 306: 1042-1049.

Minchenko AG, Stevens MJ, White L, Abatan OI, Komjáti K, Pacher P, Szabó C, Obrosova IG. 2003. Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation. FASEB J 17:1514-16. 288 kb PDF

Naidu BV, Farivar AS, Woolley SM, Fraga C, Salzman AL, Szabó C, Groves JT, Mulligan MS 2003. Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis. Exp Mol Pathol 75:12-7. 193 kb PDF

Suarez-Pinzon WL, Mabley JG, Power R, Szabó C, Rabinovitch A 2003. Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes. Diabetes 52:1683-8. 118 kb PDF

Mabley JG, Southan GJ, Salzman AL, Szabó C. 2003. The combined inducible nitric oxide synthase inhibitor and free radical scavenger, guanidinoethyldisulphide, prevents multiple-low-dose-streptozotocin-induced diabetes in vivo and interleukin-1ß-induced suppression of islet insulin secretion in vitro. Pancreas, in press 418 kb PDF

Mabley JG, Pacher P, Haskó G, Southan GJ, Salzman AL, Szabó C. 2003. Inosine protects against development of collagen-induced rheumatoid arthritis. J Autoimmunity, in press

Bai P, Mabley JG, Liaudet L, Virág L, Szabó C, Pacher P. 2003. Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity. Oncology Letti, in press

Lacza Z, Snipes JA, Zhang J, Figueroa J, Szabó C, Busija DW 2003. Mitochondria produce NO via a non-nitric oxide synthase dependent mechanism. Brain Res, in press

Bakondi E, Bai P, Erdélyi K, Szabó C, Gergely P, Virág L. 2003. Cytoprotective effect of gallotannin in oxidatively stressed HaCaT keratinocytes: the role of poly(ADP-ribose) metabolism. Exp. Dermatol, in press

Naidu BV, Fraga C, Salzman AL, Szabó C, Verrier ED, Mulligan MS. 2003. Critical role of reactive nitrogen species in lung ischemia-reperfusion injury. J Heart Lung Transplant. 22: 784-93. 272 kb PDF

Du X, Matsumura T, Edelstein D, Rosetti L, Zsengellér Z, Szabó C, Brownlee M. 2003. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J. Clin. Invest, in press. 1.57 MB PDF

Mangino M, Ametami M, Szabó C, Southard JH. 2003. Poly (ADP-Ribose) polymerase and renal hypothermic preservation injury. Am J Physiol, in press.

Murthy KGK, Deb A, Goonesekera S, Szabó C, Salzman AL. 2003. Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro. J Biol Chem, in press 456 kb PDF

Szabó C. 2003. Multiple pathways of peroxynitrite toxicity. Toxicology Letters 140:105-112. 134 kb PDF

Virág L, Szabó E, Gergely P, Szabó C. 2003. Peroxynitrite- induced cytotoxicity: mechanisms and opportunities for intervention. Toxicology Letters 140:113-124. 244 kb PDF

Liaudet L, Szabó G, Szabó C. 2003. Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite - PARP connection. Coronary Artery Dis. 14:115-122. 198 kb PDF

Southan GJ, Szabó C. 2003. Inhibitors of poly(ADP-ribose) polymerase. Current Med Chem, 10:321-340. 284 kb PDF

Szabó C. 2003. Role of flagellin in the pathogenesis of shock and ARDS: therapeutic opportunities. Crit Care Med, 31 (Suppl 1):S39-S45.

Szabó C, Szabó G, Liaudet L. 2003. Myocardial ischemia-reperfusion injury: role of the peroxynitrite -poly (ADP-ribose) synthetase pathway. In: Yearbook of Intensive Care and Emergency Medicine (Ed: J.L. Vincent) Springer-Verlag (Heidelberg, Germany) pp. 165-76.

Szabó C. 2003. Nicotinamide: a jack of all trades (but master of none?) Int Care Med, 29: 863-6

Szabó C. 2003. PARP activation and nitrosative stress in the development of cardiovascular disease in diabetes. In: Diabetes and Cardiovascular Disease, second edition (Ed: A. Veves), in press.