Inotek Publications

Prakash G. Jagtap, Garry J. Southan, Erkan Baloglu, Siya Ram, Jon G. Mabley, Anita Marton, Andrew Salzman and Csaba Szabó. 2004. The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). Bioorg. Med. Chem. Lett. 14 (2004) 81–85. 215 kb PDF

Kazunori Murakami, Perenlei Enkhbaatar, Katsumi Shimoda, Robert A. Cox, Ann S. Burke, Hal K. Hawkins, Lillian D. Traber, Frank C. Schmalstieg, Andrew L. Salzman, Jon G. Mabley, Katalin Komjáti, Pál Pacher, Zsuzsanna Zsengellér, Csaba Szabó and Daniel L. Traber. 2004. Inhibition of poly(ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock, Vol. 21, No. 2, pp. 126–133, 2004. 614 kb PDF

György Haskó, Michail V. Sitkovsky and Csaba Szabó. 2004. Immunomodulatory and neuroprotective effects of inosine. TRENDS in Pharmacological Sciences Vol.25 No.3 (March 2004) 152–157. 292 kb PDF

László Virág, Péter Bái, István Bak, Pál Pacher, Jon Mabley, Lucas Liaudet, Edina Bakondi, Pál Gergely, Márk Kollai, Csaba Szabó. 2004. Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. Med Sci Monit, 2004; 10(3): BR77-83. 1.02 MB PDF

Jon G. Mabley, Pál Pacher, Péter Bái, Rebecca Wallace, Sunali Goonesekera, László Virág, Garry J. Southan, Csaba Szabó. 2004. Suppression of intestinal polyposis in Apc-/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways. Mutation Research 58, 107-116. 285 kb PDF

Chun-Yang Xiao, Min Chen, Zsuzsanna Zsengellér, and Csaba Szabó. 2004. Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuslear Translocation of Apoptosis-Inducing Factor. The Journal of Pharmacology and Experimental Theraputics 310:1-7, 2004 2.44 MB PDF

Gábor Szabó, Pál Soós, Susanne Bährle, Zsuzsanna Zsengellér, Christa Flechtenmacher, Siegfried Hagl, Csaba Szabó. 2004. Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass. European Journal of Cardio-thoracic Surgery 25 (2004) 825–832 310 kb PDF

Alexander S. Farivar, MD, Steven M. Woolley, MRCS, Charles H. Fraga, MS, Robert Thomas, BS, Andrew L. Salzman, MD, Csaba Szabó, MD, PhD, and Michael S. Mulligan, MD. 2004. Intratracheal Poly (ADP) Ribose Synthetase Inhibition Ameliorates Lung Ischemia Reperfusion Injury. Ann Thorac Surg 2004;77:1938–43 164 kb PDF

K.G.H Murthy, C. Szabó and A.L. Salzman. 2004. Cytokines stimulate expression of inducible nitric oxide synthase in DLD-1 human adenocarcinoma cells by activating poly(A) polymerase. Inflamm. res. 53 (2004) 001-05 1.2 MB PDF

Dirk M. Maybauer, John R. Salsbury, Martin Westphal, Marc O. Maybauer, Andrew L. Salzman, Csaba Szabó, Beena B. Westphal-Varghese, Lillian D. Traber, and Daniel L. Traber. 2004. The ATP-Sensitive Potassium-Channel inhibitor Glibenclamide improves outcome in an ovine model of hemorrhagic shock. SHOCK, Vol. 22, No. 4, pp. 387–391, 2004 376 kb PDF

Lacza Z, Horn T, Snipes J, Zhang J, Roychowdhury S, Horvath E, Figueroa J, Kollai M, Szabó C, Busija D. Lack of mitochondrial nitric oxide production in the mouse brain. Journal of Neurochemistry, 2004, 90, 942-951 1.8 MB PDF

Pacher P, Vaslin A, Benko R, Mabley J, Liaudet L, Haskó G, Marton A, Batkai S, Kollai M, Szabó C. A new, Potent Poly(ADP-ribose) Polymerase inhibior improves cardiac and vascular dysfunction associated with advance aging. JPET 311L1-7, 2004 1.37 MB PDF

Scott G, Kean R, Mikheeva T, Fabis M, Mabley J, Szabó C, Hooper D. The Therapeutic effects of PJ34 (N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCI), a selective inhibitor of Poly(ADP-Ribose)Polymerase, in Experimental Allergic Encephalomyelitis are Associated with Immunomodulation. JPET 310:1053-1061, 2004 1.92 MB PDF

Szabó C. Role of Poly (ADP-ribose) Polymerase activation in the pathogenesis of inflammation and circulatory shock. Abstract, 2004 2.84 MB PDF

Farivar A, Woolley S, Naidu B, Fraga C, Byrne K, Thomas R, Salzman A, Szabó C, Mulligan M. Poly (ADP) ribose synthetase inhibition reduces obliterative airway disease in rat tracheal allografts. J Heart Lung Transplant 2004; 23:993-1002 3.88 MB PDF

Benko R, Pacher P, Vaslin A, Kollai M, Szabó C. Restoration of the endothelial function in the aortic rings of apolipoprotein E deficient mice by pharmacological inhibition of the nuclear enzyme poly(ADP-ribose) polymerase. Life Sciences 75 (2004) 1255-1261 853 kb PDF

Szabó G, Liaudet L, Hagl S, Szabó C. Poly(ADP-ribose) polymerase activation in the reperfused myocardium. Cardovascular Research 61 (2004) 471-480 3.18 MB PDF

Pacher P, Mabley M, Liaudet L, Evgenov O, Marton A, Haskó G, Kollai M, Szabó C. Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure. Am J Physiol Heart Circ Physiol 287: H1-H6 1.22 MB PDF

Nemeth Z, Wong H, Odoms K, Deitch E, Szabó C, Vizi E, Haskó G. Proteasome inhibitors induce inhibitory kB (IkB) kinase activation, IkBa degradation, and nuclear factor kB activation in HT-29 cells. Mol Pharmacol 65:342-349, 2004 1.51 MB PDF

Jagtap P, Chen Z, Szabó C, Klotz K. 2-(N-Acyl) and 2-N-acyl-N6-substituted analogues of adenosine and their affinity at the human adenosine receptors. Bioorganic & Medicinal Chemistry Letters 14 (2004) 1495-1498 537 kb PDF

Obrosova I, Minchenko A, Frank R, Seigel G, Zsengellér Z, Pacher P, Stevens M, Szabó C. Poly (ADP-ribose) polymerase inhibitors counteract diabetes-and hyposiz-induced retinal vascular endothelial growth factor overexpression. Internatinal Journal of Molecular Medicine 14: 55-64, 2004 3.31 MB PDF

Mabley J, Phil D, Southan G, Salzman A, Szabó C. The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes In Vitro and Interleukin-1B-Induced Suppression of Islet Insulin Secretion In Vitro. Pancreas 2004; 28:e39-e44 1.0 MB PDF

Chen M, Zsengellér Z, Xiao C, Szabó C. Mitochondrial-to-nuclear translocation of apoptosis-inducing factor in cardiac myocytes during oxidant stress: potential role of poly(ADP-ribose) polymerase-1. Cardiovascular Research 63 (2004) 682-688 1.5 MB PDF

Li F, Szabó C, Pacher P, Southan G, Abatan O, Charniauskaya T, Stevens M, Obrosova I. Evaluation of orally active poly (ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy. Diabetologia (2004) 47:710-717 1.54 MB PDF

Nemeth Z, Deitch E, Davidson M, Szabó C, Vizi E, Haskó G. Disruption of the Actin Cytoskeleton results in Nuclear Factor-kB activation and inflammatory mediator production in cultured huan intestinal epithelial cells. Journal of Cellular Physiology 200:71-81 (2004) 2.24 MB PDF

Szabó C, Pacher P, Zsengellér Z, Vaslin A, Komjati K, Benko R, Chen M, Mabley J, Kollai M. Angiotensin II-Mediated Endothelial Dysfunction: Role of poly (ADP-ribose) polymerase activation. Molecular Medicine, Volume 10, 1-3, 2004 1.66 MB PDF

Brock W, Milas L, Bergh S, Lo R, Szabó C, Mason K. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) poluymerase. Cancer Letters 205 (2004) 155-160 758 kb PDF