Inotek Publications

Szabó C, Zingarelli B, O'Connor M, Salzman AL. 1996. DNA strand breakage, activation of poly-ADP ribosyl synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite. Proc Natl Acad Sci USA 93:1753-1758. 245 kb PDF

Zingarelli B, O'Connor M, Wong, H., Salzman AL, Szabó C. 1996. Peroxynitrite-mediated DNA strand breakage activates poly-ADP ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide. J Immunol 156:350-358. 1.5 MB PDF

Murrell GAC, Dolan MA, Szabó C, Warren RF, Hannafin, JA. 1996. Nitric oxide: an important articular free radical. J Bone Joint Surg 78A:265-274.

Salzman AL, Denenberg AG, Ueta I, O'Connor M, Linn S, Szabó C. 1996. Characterization of the induction and activity of the human nitric oxide synthase in a transformed intestinal epithelial cell line. Am J Physiol 270:G565-573. 1.5 MB PDF

Southan GJ, Zingarelli B, O'Connor M, Salzman AL, Szabó C. 1996. Spontaneous rearrangement of aminoalkylguanidines into mercaptoalkylguanidines - a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117:619-632. 2.8 MB PDF

Southan GJ, Salzman AL, Szabó C. 1996. Potent inhibition of the inducible isoform of nitric oxide synthase by aminoethylselenourea and related compounds. Life Sci 58:1139-1148. 1.2 MB PDF

Arkovitz M, Garcia VF, Wispe JR, Szabó C. 1996. Selective inhibition of the inducible isoform of nitric oxide synthase inhibits endotoxin-induced pulmonary leak. J Pediatric Surgery 31:1009-1015.

Jang D, Szabó C, Murrell G. 1996. Isothioureas are specific and potent inhibitors of inducible nitric oxide synthase in cartilage. Eur J Pharmacol 312:341-347. 1.03 MB PDF

Haskó G, Szabó C, Merkel K, Bencsics A, Zingarelli B, Vizi ES. 1996. Modulation of lipopolysaccharide-induced tumor necrosis factor and nitric oxide production by dopamine receptor agonists and antagonists in mice. Immunology Lett 49:143-147. 1.05 MB PDF

Zingarelli B, Salzman AL, Szabó C. 1996. Protective effects of nicotinamide against nitric oxide-mediated vascular failure in endotoxic shock: potential involvement of polyADP ribosyl synthetase. Shock 5:258-264. 1 MB PDF

Szabó C, Zingarelli B, Salzman AL. 1996. Role of poly-ADP ribosyltransferase activation in the nitric oxide- and peroxynitrite-induced vascular failure. Circ Res 78:1051-1063. 3.47 MB PDF

Szabó C, Day BJ, Salzman AL. 1996. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages, using a novel mesoporphyrin superoxide dismutase analog and peroxynitrite scavenger. FEBS Lett 381:82-86. 853 kb PDF

Szabó C, Salzman AL. 1996. Inhibition of ATP-activated potassium channels improves blood pressure and survival rate in acute severe hemorrhagic shock in the rat. Shock 5:391-394. 575 kb PDF

Vromen A, Szabó C, Southan G, Salzman AL. 1996. Protective effects of isopropyl-isothiourea, a potent inhibitor of constitutive nitric oxide synthase in rodent and porcine models of hemorrhagic shock. J Appl Physiol 81:707-715. 1.4 MB PDF

Szabó C, Salzman AL. 1996. Inhibition of terminal calcium overload protects against peroxynitrite-induced cellular injury in macrophages. Immunol Lett 51:163-167. 1.21 MB PDF

Szabó C, Bryk R, Zingarelli B, Southan GJ, Gahman TC, Bhat V, Salzman AL, Wolff DJ. 1996. Pharmacological characterization of guanidine-ethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform. Br J Pharmacol 118:1659-1668. 2.15 MB PDF

Saavedra JE, Southan GJ, Davies KM, Lundell A, Markou C, Hanson SR, Adrie C, Hurford WE, Zapol WM, Keefer LK. 1996. Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor. J Med Chem 39:4361-5.

Szabó C. 1996. Nitric oxide, intracellular calcium overload and cytotoxicity. Shock 6:25-26.

Benyó Z, Szabó C, Velkei MH, Bohus B, Wahl M, Sándor P. 1996. Intravenous beta-endorphin administration fails to alter hypothalamic blood flow in rats expressing normal or reduced nitric oxide synthase activity. Peptides 17:733-736.

Southan GJ, Szabó C, Salzman AL. 1996. 2-Aminopyridines are competitive inhibitors of nitric oxide synthases with potent pressor actions; Pharmacology Communications 7:275-286. 1.61 MB PDF

Haskó G, Szabó C, Németh ZH, Kvetan V, Pastores SM, Vizi ES. 1996. Adenosine receptor agonists differentially regulate IL-10 and TNF production in endotoxemic mice. J Immunol 157:4634-4640. 1.2 MB PDF

Vromen A, Arkovitz MS, Zingarelli B, Salzman AL, Garcia VF, Szabó C. 1996. Low-level expression and limited role for the inducible isoform of nitric oxide synthase in the vascular hyporeactivity and mortality associated with cecal ligation and puncture in the rat. Shock 6:248-253. 898 kb PDF

Szabó C, Kilbourn RG. 1996. Nitric oxide and septic shock. JAMA 276:781.

Szabó C, Wong HR, Salzman AL. 1996. Heat shock phenotype inhibits peroxynitrite-induced activation of poly(ADP) ribosyl synthetase and protects against peroxynitrite cytotoxicity in J774 macrophages. Eur J Pharmacol 315:221-226. 1.14 MB PDF

Gilad E, Zingarelli B, O'Connor M, Salzman AL, Bertók L, Szabó C. 1996. Effects of radio-detoxified endotoxin on nitric oxide production in J774 macrophages and in endotoxin shock. J Endotoxin Res 3:513-516. 1.15 MB PDF

Szabó C. 1996. Role of nitric oxide in the central nervous system. Brain Research Bulletin 41:131-141. 2.51 MB PDF

Szabó C. 1996. DNA strand breakage and activation of poly-ADP ribosyltransferase: a cytotoxic pathway triggered by peroxynitrite. Free Radical Biol Med 21:855-869. 3.93 MB PDF

Southan GJ, Szabó C. 1996. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol 51:383-394. 2.30 MB PDF