1997 Publications

  • Szabó C, Saunders C, O’Connor M, Salzman AL. 1997. Peroxynitrite causes energy depletion and increases permeability via activation of poly-ADP ribosyl synthetase in pulmonary epithelial cells. Am J Resp Mol Cell Biol 16:105-109.
  • Szabó C, Haskó G, Németh ZH, Kvetan V, Pastores SM, Vizi ES. 1997. Isoproterenol regulates tumor necrosis factor, interleukin-10, interleukin-6 and nitric oxide production and protects against the development of vascular hyporeactivity in endotoxemia. Immunology 90:95-100.
  • Zingarelli B, Day BJ, Crapo J, Salzman AL, Szabó C. 1997.C35 The potential involvement of peroxynitrite in the pathogenesis of endotoxic shock. Br J Pharmacol 120:259-267.
  • Zingarelli B, Southan GJ, Gilad E, Salzman AL, Szabó C. 1997. Mercaptoalkylguanidines are direct inhibitors of cyclooxygenase activity. Br J Pharmacol 120:357-366.
  • Salzman AL, Vromen A, Denenberg A, Szabó C. 1997. Protective effects of glibenclamide, an inhibitor of ATP-activated potassium channels in a porcine model of hemorrhagic shock. Am J Physiol 272:H688-697.
  • Menconi MJ, Salzman AL, Unno N, Ezzell RM, Casey DM, Brown DA, Tsuji Y, Fink MP. 1997. Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers. Am J Physiol 272:G1007-21.
  • Arkovitz M, Szabó C, McConnell, K, Bove K, Garcia V, Wispé J. 1997. Decreased pulmonary compliance is an early indicator of pulmonary oxygen injury. J Surg Res 67: 193-198.
  • Linn C, Morelli PJ, Edry I, Cottongim SE, Szabó C, Salzman AL. 1997. Promoter analysis of the human inducible nitric oxide synthase gene suggests both transcriptional and post-transcriptional regulation. Am J Physiol 272: G1499-1508.
  • Gilad E, Cuzzocrea S, Zingarelli B, Salzman AL, Szabó C. 1997. Melatonin is a scavenger of peroxynitrite. Life Sci 60:PL169-174.
  • Szabó C, Haskó G, Németh Z, Vizi ES. 1997. Calcium entry blockers increase interleukin-10 production in endotoxemic mice. Shock 7:302-307.
  • Sun X, Wei S, Szabó C, Dusting GJ. 1997. Depression of the inotropic action of isoprenaline by nitric oxide synthase induction in rat isolated hearts. Eur J Pharmacol 320:29-35.
  • Hrabák A, Bajor T, Southan GJ, Salzman AL, Szabó C. 1997. Comparison of the inhibitory effect of isothiourea and mercaptoalkylguanidine nitric oxide synthase inhibitors on arginase and nitric oxide synthase activity. Life Sci 60:PL395-401.
  • Murrell GAC, Szabó C, Hannafin, JA, Jang D, Dolan MM, Deng XH, Doty SB, Warren RF. 1997. Modulation of tendon healing by nitric oxide. Inflammation Res 46:19-27.
  • Invernizzi P, Salzman AL, Ueta I, O’Connor M, Szabó C, Setchell K. 1997. Ursodeoxycholate inhibits the induction of nitric oxide synthase in a human intestinal epithelial cell line and in vivo. Am J Physiol 273:G131-138.
  • Németh Z, Haskó G, Szabó C, Vizi ES. 1997. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice. Shock 7:371-375.
  • Szabó C, Ferrer-Sueta G, Zingarelli B, Southan GJ, Salzman AL, Radi R. 1997. Mercapto-ethylguanidine and related guanidine nitric oxide synthase inhibitors react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J Biol Chem 272:9030-9036.
  • Arkovitz M, Szabó C, Garcia V, Wispé J. 1997. The effect of hyperoxia on the constitutive and inducible isoforms of nitric oxide synthase in the lung. Shock 7:345-350.
  • Krafte-Jacobs B, Brilli R, Szabó C, Denenberg A, Moore L, Salzman AL. 1997. Circulating methemoglobin, nitrate and nitrite concentrations as indicators of nitric oxide overproduction in critically ill children with septic shock. Critical Care Med 25:1588-1593.
  • Szabó C, Wong HR, Bauer PI, Kirsten E, O’Connor M, Zingarelli B, Mendeleyev J, Haskó G, Vizi ES, Salzman AL, Kun E. 1997. Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, and inhibitor of poly (ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways. Int J Oncol, 10:1093-1101.
  • Cuzzocrea S, Zingarelli B, Costantino G, Szabó A, Salzman AL, Caputi AP, Szabó C. 1997. Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusion. Br J Pharmacol 121:1065-1074.
  • Southan GJ, Gauld D, Lubeskie A, Zingarelli B, Cuzzocrea S, Salzman AL, Szabó C, Wolff, DJ. 1997. Inhibition of nitric oxide synthase with 1H- pyrazole-1-carboxamidine and related compounds. Biochem Pharmacol 54:409-417.
  • Suarez-Pinzon WL, Szabó C, Rabinovitch A. 1997. Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet beta-cells. Diabetes 46:907-911.
  • O’Connor M, Salzman AL, Szabó C. 1997. Role of peroxynitrite in the protein oxidation and apoptotic DNA fragmentation in immunostimulated vascular smooth muscle cells. Shock 8:439-443
  • Szabó C, O’Connor M, Salzman AL. 1997. Endogenously produced peroxynitrite induces the oxidation of mitochondrial and nuclear proteins in immunostimulated macrophages. FEBS Lett 409:147-150.
  • Zingarelli B, Cuzzocrea S, Zsengeller, Z, Salzman AL, Szabó C. 1997. Beneficial effect of inhibition of poly-ADP ribose synthetase activity in myocardial ischemia-reperfusion injury. Cardiovasc Res 36:205-215.
  • Szabó C, Cuzzocrea S, Zingarelli B, O’Connor M, Salzman AL. 1997. Endothelial dysfunction in endotoxic shock: importance of the activation of poly (ADP ribose) synthetase (PARS) by peroxynitrite. J Clin Invest 100:723-735.
  • Szabó C. 1997. Nitric oxide, peroxynitrite and poly (ADP-ribose) synthetase in anaphylactic shock. Shock, 8:153-154.
  • Cuzzocrea S, Zingarelli B, Hake P, Gilad E, Salzman AL, Szabó C. 1997. Protective effect of melatonin in carageenan-induced models of local inflammation. Relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity. J Pineal Res, 23:106-116.
  • Cuzzocrea S, Zingarelli B, O’Connor M, Salzman AL, Szabó C. 1997. Role of peroxynitrite and activation of poly (ADP-ribose) synthetase in the vascular failure induced by zymosan-activated plasma. Br J Pharmacol 122:493-503.
  • Gilad E, Zingarelli B, Salzman AL, Szabó C. 1997. Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts in vitro. J Mol Cell Cardiol 29:2585-2597.
  • Brilli RJ, Krafte-Jacobs B, Smith D, Roselle D, Passerini D, Vromen A, Moore L, Szabó C, Salzman AL. 1997. Intratracheal instillation of a novel NO/nucleophile adduct selectively reduces pulmonary hypertension. J Appl Physiol 83:1968-1975.
  • Gardner PR, Constantino G, Szabó C, Salzman AL.1997. Nitric oxide sensitivity of the aconitases. J Biol Chem 272:25071-25076.
  • Szabó C, Lim LH, Cuzzocrea S, Getting SJ, Zingarelli B, Flower RJ, Salzman AL, Perretti M. 1997. Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment. J Exp Med, 186:1041-1049.
  • Parikh A, Salzman AL, Fischer JE, Szabó C, Hasselgren PO. 1997. Interleukin-1 and interferon-gamma regulate interleukin-6 production in human intestinal epithelial cells. Shock 8:249-255.
  • Cuzzocrea S, Tailor A, Zingarelli B, Salzman AL, Flower RJ, Szabó C, Perretti M. 1997. Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration. J Immunol 159:5089-5097.
  • Zingarelli B, Ischiropoulos H, Salzman AL, Szabó C. 1997. Amelioration by mercapto-ethylguanidine of the vascular and energetic failure in hemorrhagic shock in the anesthetized rat. Eur J Pharmacol 338:55-65.
  • Németh Z, Szabó C, Haskó G, Salzman AL, Vizi ES. 1997. Effect of the PDE III inhibitor amrinone on cytokine and nitric oxide production in immunostimulated J774.1 macrophages. Eur J Pharmacol 339:215-221.
  • Kilbourn RG, Szabó C, Traber D. 1997. Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: lessons learned from experimental and clinical studies Shock 7:235-246.
  • Szabó C, Salzman AL. 1997. Nitric oxide in the lung. In: Pediatric Lung (Wilmott RW, ed.) Birkhauser Verlag, Basel, Switzerland, 279-310.
  • Szabó C. 1997. Role of poly (ADP-ribose) synthetase activation in suppression of cellular energetics in response to nitric oxide and peroxynitrite. Biochem Soc Transact 25:841-846.
  • Kilbourn RG, Traber D, Szabó C. 1997. Role of nitric oxide in the vascular failure in shock. Disease-A-Month 43:277-348.
  • Szabó C, Ohshima H. 1997. DNA injury induced by peroxynitrite. Nitric Oxide Biol Chem 1:323-385.